Lab Publications

José-Edwards, D.S., Kerner, P., Kugler, J.E., Deng, W., Jiang, D. and Di Gregorio, A.: The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the Brachyury gene regulatory network. Developmental Dynamics, 240:1793-1805, 2011. [PubMed] [PDF]

Kugler, J.E.*, Kerner, P.*, Bouquet, J.-M., Jiang, D. and Di Gregorio, A.: Evolutionary changes in the notochord genetic toolkit: a comparative analysis of notochord genes in the ascidian Ciona and the larvacean Oikopleura. BMC Evol. Biol. 11: 21, 2011 (*equal contribution). [PubMed] [PDF] This article is the subject of a commentary: Ferrier, D.E. “Tunicates push the limits of animal evo-devo.” BMC Biol. (2011) 9:3.

Kugler, J.E., Gazdoiu, S., Oda-Ishii, I., Passamaneck, Y.J., Erives, A.J., and Di Gregorio, A.: Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis. J. Cell Sci. 123: 2453-2463, 2010. [PubMed] [PDF] Featured in Development 137(15) as "Article of interest in other CoB journals".

Passamaneck, Y.J., Katikala, L., Perrone, L., Dunn, M.P., Oda-Ishii, I., and Di Gregorio, A.: Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis. Development. 136: 3679-3689, 2009. [PubMed] [PDF]

Dunn, M.P. and Di Gregorio, A.: The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord. Dev. Biol. 328: 561-574, 2009. [PubMed] [PDF]

Capellini, T.D.*, Dunn, M.P.*, Passamaneck, Y.J., Selleri, L. and Di Gregorio, A.: Conservation of notochord gene expression across chordates: insights from the Leprecan gene family. Genesis - Special Issue on Chordate Origins and Evolution. Genesis. 46:683-696, 2008. [PubMed] [PDF]

Kugler, J.E., Passamaneck, Y.J, Feldman, T.G., Beh, J., Regnier, T.W. and Di Gregorio. A.: - Evolutionary conservation of vertebrate notochord genes in the ascidian Ciona intestinalis. Genesis - Special Issue on Chordate Origins and Evolution. Genesis. 46:697-710, 2008. [PubMed] [PDF]

Capellini, T.D., Zewdu, R., Di Giacomo, G., Asciutti, S., Kugler, J.E., Di Gregorio, A. and Selleri, L.: - Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev. Biol. 321:500-514, 2008. [PubMed] [PDF]

Coric, T., Passamaneck, Y.J., Zhang, P., Di Gregorio, A. and Canessa, C.M.: - Simple chordates exhibit a proton-independent function of acid-sensing ion channels. FASEB J. 6:1914-1923, 2008. [PubMed] [PDF]

Passamaneck, Y., Hadjantonakis, A.-K., and Di Gregorio, A.: - Dynamic and Polarized Muscle Cell Behaviors Accompany Tail Morphogenesis in the Ascidian Ciona intestinalis. PLoS ONE 2, e714: 1-13, 2007. [PubMed] [PDF]

Oda-Ishii, I., and Di Gregorio, A.: - Lineage-Independent Mosaic Expression and Regulation of the Ciona multidom Gene in the Ancestral Notochord. Dev. Dyn. 236: 1806-1819, 2007. [PubMed] [PDF] Images from the article featured in the Art Pix section, Dev. Dyn. September 2007.

Di Gregorio, A., and Hadjantonakis, A.-K.: - The multidimensionality of cell behaviors underlying morphogenesis: a case study in ascidians. Bioessays 28:874-879, 2006. [PubMed] [PDF]

Passamaneck, Y.J., Di Gregorio, A., Papaioannou, V.E. and Hadjantonakis, A.-K.: - Live imaging of fluorescent proteins in chordate embryos: from ascidians to mice. Micr. Res. Tech. 69: 160-167, 2006. [PubMed] [PDF] Highlighted in Microscopy and Analysis (2006) 20: 37.

Rhee, J.M., Oda-Ishii, I., Passamaneck, Y.J., Hadjantonakis, A.-K. and Di Gregorio, A.: - Live imaging and morphometric analysis of embryonic development in Ciona intestinalis. Genesis 43: 136-147, 2005. [PubMed] [PDF]

Passamaneck, Y.J. and Di Gregorio, A.: - Ciona intestinalis: chordate development made simple. Dev. Dyn. 233: 1-19, 2005. [PubMed] [PDF]

Previous Publications

Keys, D.N., Lee, B.I., Di Gregorio, A., et al. - A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis. PNAS 102: 679-683, 2005. [PubMed] [PDF]

Spagnuolo, A.*, Ristoratore, F.*, Di Gregorio, A.*, Aniello, F., Branno, M. and Di Lauro, R. - Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Gene 309: 71-79, 2003. (*equal contribution) [PubMed] [PDF]

Wada, S., Tukuoka, M., Shoguchi, E., Kobayashi, K., Di Gregorio, A., et al. - A genomewide survey of developmentally relevant genes in Ciona intestinalis.II. Genes for homeobox transcription factors. Dev. Genes Evol. 213: 222-234, 2003. [PubMed] [PDF]

Di Gregorio, A., Harland, R. M., Levine, M. and Casey, E. S.: - Tail morphogenesis in the ascidian, Ciona intestinalis, requires cooperation between notochord and muscle. Dev. Biol. 244: 385-395, 2002. [PubMed] [PDF]

Di Gregorio, A. and Levine, M.: - Analyzing gene regulation in ascidian embryos: new tools for new perspectives. Differentiation 70: 132-139, 2002. [PubMed] [PDF]

Dehal, P., Satou, Y., Campbell, R. K., Chapman, J., Degnan, B., De Tomaso, A., Davidson, B., Di Gregorio, A., et al.: - The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science 298: 2157-2167, 2002. [PubMed] [PDF]

Di Gregorio, A., Corbo, J. C. and Levine, M.: - The regulation of forkhead/HNF-3b expression in the Ciona embryo. Dev. Biol. 229: 31-43, 2001. [PubMed] [PDF]

Corbo, J.C., Di Gregorio A. and Levine, M.: - The ascidian as a model organism in developmental and evolutionary biology. Cell 106: 535-538, 2001. [PubMed] [PDF]

Caracciolo, A.*, Di Gregorio, A.*, Aniello, F., Di Lauro, R. and Branno, M. - Identification and developmental expression of three Distal-less homeobox-containing genes in the ascidian Ciona intestinalis. Mech. Dev. 88: 123-126, 2000. (*equal contribution) [PubMed] [PDF]

Di Gregorio, A. and Levine, M.: - Regulation of Ci-tropomyosin-like, a Brachyury target gene in the ascidian, Ciona intestinalis. Development 126: 5599-5609, 1999. [PubMed] [PDF]

Takahashi, H., Hotta, K., Erives, A., Di Gregorio, A., Zeller, R.W., Levine, M. and Satoh, N.: - Brachyury downstream notochord differentiation in the ascidian embryo. - Genes Dev 13: 1519-1523, 1999. [PubMed] [PDF]

Aniello, F., Locascio, A., Villani, M.G., Di Gregorio, A., Fucci, L. and Branno, M.: - Identification and developmental expression of Ci-msxb: a novel homologue of Drosophila msh gene in Ciona intestinalis. - Mech Dev 88: 123-126, 1999. [PubMed] [PDF]

Corbo, J.C., Fujiwara, S., Levine, M. and Di Gregorio, A. - Suppressor of Hairless activates Brachyury expression in the Ciona embryo. Dev. Biol., 203: 358-368, 1998. [PubMed] [PDF]

Di Gregorio, A. and Levine, M. - Ascidian embryogenesis and the origins of the chordate body plan. - Curr. Opin. Genet. Dev. 8:457-463, 1998. [PubMed] [PDF]

< a href="covers/Calmodulin-COVER.jpg"> Di Gregorio, A., Villani, M.G., Locascio A., Ristoratore, F., Aniello, F. and Branno, M. - Developmental regulation and tissue-specific localization of calmodulin mRNA in the protochordate Ciona intestinalis. Mech. Dev. 40: 387-394, 1998. [PubMed] [PDF]

Gionti, M., Ristoratore, F., Di Gregorio, A., Aniello, F., Branno, M. and Di Lauro, R.: - Cihox5, a new Ciona intestinalis Hox-related gene, is involved in regionalization of the spinal cord. - Dev Genes Evol 207: 515-523, 1998. [PubMed] [PDF]

Corbo, J.C., Erives, A., Di Gregorio, A., Chang, A. and Levine, M. - Dorsoventral patterning of the neural tube is conserved in a protochordate. Development 124: 2335-2344, 1997. [PubMed] [PDF]

Di Gregorio, A., Spagnuolo, A., Ristoratore, F., Pischetola, M., Aniello, F., Branno, M., Cariello, L. and Di Lauro, R. - Cloning of ascidian homeobox genes provides evidence for a primordial chordate cluster. Gene 156: 253-257, 1995. [PubMed] [PDF]

Fucci, L., Piscopo, A., Aniello, F., Di Gregorio, A., Calogero, R., Branno, M. and Geraci, G.: - Cloning and characterization of a developmentally regulated sea urchin cDNA encoding glutamine synthetase. - Gene 152: 205-208, 1995. [PubMed] [PDF]

Published Abstracts and Book Chapters

Giebing, T., Langer, M., Serwe, C., Di Gregorio, A., Di Lauro, R. and D'Haese, J.: Gelsolin-like proteins from Tunicates - Analytical approach at both protein and DNA level. J. Muscle Res. Cell. Motil. 17: 111, 1996.

Di Gregorio, A. and Levine, M.: T-box genes and the development of axial tissues in Ciona intestinalis. In: "Biology of Ascidians”, H. Sawada, H. Yokosawa, and C. C. Lambert eds., Springer-Verlag, Tokyo, 2001.

Di Gregorio, A., Casey, E. S., Harland, R. M. and Levine, M.: Tail morphogenesis in the ascidian, Ciona intestinalis. Dev. Growth Differ. 43 (supplement): S66, 2001.

Di Gregorio, A., Kugler, J.E., Oda-Ishii, I., Keys, D.N., Imai, J.H., DeWan, A., Ott, J. and Richardson, P.M.: Gene regulation in the ancestral notochord: insights from a collection of cis-regulatory elements from the ascidian Ciona intestinalis. Dev. Biol. 306: 350, 2007.

Di Gregorio A. The Brachyury Locus. In Brenner’s Online Encyclopedia of Genetics, ed. Dr. Stanley Maloy and Kelly Hughes. In press.